diff --git a/Meta/run.sh b/Meta/run.sh
index e771290690..80755cff80 100755
--- a/Meta/run.sh
+++ b/Meta/run.sh
@@ -57,6 +57,10 @@ SERENITY_SCREENS="${SERENITY_SCREENS:-1}"
 SERENITY_QEMU_DISPLAY_BACKEND="${SERENITY_QEMU_DISPLAY_BACKEND:-sdl,gl=on}"
 if [ "$SERENITY_SCREENS" -gt 1 ]; then
     SERENITY_QEMU_DISPLAY_DEVICE="virtio-gpu,max_outputs=$SERENITY_SCREENS "
+    # QEMU appears to always relay absolute mouse coordinates relative to the screen that the mouse is
+    # pointed to, without any way for us to know what screen it was. So, when dealing with multiple
+    # displays force using relative coordinates only
+    SERENITY_KERNEL_CMDLINE="$SERENITY_KERNEL_CMDLINE vmmouse=off"
 else
     SERENITY_QEMU_DISPLAY_DEVICE="VGA,vgamem_mb=64 "
 fi